100% Natural Superfood 99% Restore NMN NMNH Powder- Improves Fertility- Improves Symptoms of Serious Disease- Free Shipping

Other Names:Reduced beta-nicotinamide mononucleotide
Appearance:White or yellowish Powder
Specifcation: 99%
Shelf Life :2 Years
99% NMNH powder Anti-aging Reduced beta-nicotinamide mononucleotide CAS 108347-85-9 Reduced NMN NMNH
The other name of NMNH is “reduced β-nicotinamide mononucleotide”, which is the reduced form of NMN. The molecular formula of NMNH is C11H17N2O8P, molecular weight: 336.23g/mol, CAS No.: 108347-85-9, is a non- Shaped yellow powder. The latest research literature shows that NMNH increases NAD+ levels faster and at higher concentrations, with an average of 5 times that of NMN. NMNH has been industrialized and developed with a purity of ≥99%. It has two forms of free acid and sodium salt.

1.99% NMNH powder Anti-aging Reduced beta-nicotinamide mononucleotide CAS 108347-85-9 Reduced NMN NMNH1. NMNH can rapidly increase NAD+ in vitro
The researchers used both NMN and NMNH to test their ability to increase NAD+ levels in cells in vitro. Different concentrations of NMN and NMNH were added to the hepatocytes of AML12, and it was found that compared with NMN, NMNH not only significantly increased the level of NAD+ in cells, but also accelerated the rate of increase of NAD+ concentration.

2. NMNH acts as a potent NAD+ enhancer in vitro.
To further demonstrate that NMNH can act as a highly efficient NAD+ precursor, the researchers added the same concentration of NMN and NMNH.
The experimental results show that adding NMNH can increase the NAD+ content in these cells and is more effective than NMN at the same concentration.

3. NMNH can increase the concentration of NAD+ in vivo
In order to evaluate the role of NMNH and NMN in vivo, the experimenter injected C57BL/6N mice with vehicle fluid (PBS) or 250 mg/kg of NMN/NMNH, followed by blood collection (1, 4, 20 hours), and in Tissue collection was performed 24 hours later.
The results show that NMNH can effectively increase the concentration of NAD+ in the blood, and the NAD+ level can be rapidly increased within 1 hour after supplementation, which is much higher than that of NMN. It is worth noting that the NAD+ content in the blood dropped to the basal level 4 hours after NMN supplementation, but NMNH maintained a more than 2-fold increase in NAD+ concentration within 20 hours after the first injection.
The researchers also found that NMNH increased NAD+ levels in a variety of tissues compared to NMN, with the liver (5-fold increase) and kidney (2-fold increase) having the greatest effect. Surprisingly, NMNH also significantly increased NAD+ levels in the brain, gastrocnemius muscle, brown adipose tissue and heart, something NMN could not do.

4. NMNH can repair tubular epithelial cells
NAD+ homeostasis is critical for repairing damaged epithelial cells and maintaining cellular biological activity. In particular, the researchers observed whether NMNH could protect tubular epithelial cells from hypoxia/reoxygenation injury by enhancing repair.
In normoxic environment, supplementing the same concentration of NMNH and NMN can increase the concentration of NAD+ by 5 times and 2 times respectively; in hypoxia/reoxygenation environment, NMNH and NMN can increase the NAD+ concentration higher.
After analysis, NMNH supplementation can reduce cellular damage in hypoxia/reoxygenation injury and enhance cellular repair capacity by targeting NAD+ regeneration, enhancing mitochondrial activity and nucleotide metabolism.
NMNH can increase the accumulation of intracellular NADH, inhibit cellular glycolysis and the tricarboxylic acid cycle (TCA cycle), and inhibit cell growth, while NMN can only limit cellular glycolysis.

Improves fertility

Revitalizes Reproduction

With age comes fertility problems, especially with women. This stems from problems with oocyte (egg) quality. NMN has been shown to improve the age-related decline in oocyte quality and number, as well as female fertility . NMN also protects oocytes from toxins.

Taking NMN may provide improvements in fertility in both men and women.

As female ages, her eggs (oocytes) quality and fertility decline. Studies have shown that by supplementing with NMN, the benefits included increased ovulation, improved cell division, and the ability to achieve fertilization.

As men age, spermatogenesis (sperm production) decreases. Early studies suggest that this decline in sperm production occurs secondary to the depleting levels of NAD+ that accompany aging. This may support using NMN supplements to improve low sperm counts as men age. Furthermore, the effects of obesity on sperm quality may be mitigated by NMN’s positive effects.

Improves symptoms of serious disease

Researchers are also exploring the benefits of increased NAD levels on high blood pressure, liver health and diabetes.

Inside the body, NAD+ produced by NMN supplements stimulates the activity of mitochondria, microscopic organelles that are vital to our metabolism. The powerhouses of the cells, mitochondria transform glucose and oxygen into cellular energy – without them, cells would lack energy and die.

NAD+ NMNH also activates sirtuins, a family of proteins that repair our DNA and regulate cellular homeostasis. Each time our cells divide, the caps on the ends of our DNA strands become slightly shorter; this fraying and shortening damage our DNA, but sirtuins reduce this process by stabilizing these caps, or telomeres. Studies in mice show that feeding them NMN can elongate telomeres, offsetting the risk of DNA damage.

Interestingly, sirtuins are NAD-dependent, which means they can’t function properly without it. However, as NAD production increases, so too does sirtuin activity.

Promotes Organ Health

In addition to slowing down aspects of the aging brain, vasculature, muscle, heart, metabolism, and eye, NMN has also been shown to rejuvenate bone stem cells and promote bone formation. It also reverses intestinal aging, protects against age-related kidney deterioration, and inhibits the onset of liver fibrosis. Thus, NMN also slow aspects of aging bone, intestines, kidney and liver.

Enhances Maintenance of DNA Repair

Our DNA codes for the building blocks of our cells but accumulates damage as we age. Repairing DNA damage can prevent age-related diseases. NAD+ fuels enzymes called sirtuins — sometimes thought of as the guardians of our healthspan. Sirtuins play a key role in repairing DNA.

Also, each time our cells divide, the DNA at the ends of our chromosomes (telomeres) grow shorter. At a certain point, this telomere shortening begins to damage our genes and cells. Sirtuins slow this process by stabilizing telomere length.

Since sirtuins rely upon NAD+ to function, there has been an effort to enhance sirtuin activity through NAD+ boosting methods. Along these lines, studies have demonstrated that feeding  NMN activates sirtuins. NMN also repairs DNA damage resulting from radiation and old age. Furthermore, in humans, NMN increases telomere length.