What is rutin?

Rutin is a bioflavonoid, or plant pigment, that is found in certain vegetables and fruits. Apples are full of rutin. Buckwheat, most citrus, figs, and both black and green tea also contain rutin.

Rutin has powerful antioxidant properties. It also helps your body produce collagen and use vitamin C. You can add rutin to your diet by eating foods that contain it or taking it in supplement form.

Although there are no U.S. Food and Drug Administration (FDA) guidelines for use of rutin due to lack of research, this bioflavonoid is commonly used medicinally. It’s included in more than 130 registered therapeutic medicinal preparationsTrusted Source. It’s also thought to have a number of health benefits.

 

TEST                      EP8 RESULTS                 Test Method
Appearance Light greenish yellow powder Complies Visual
Identification B.IR absorbance Matching IR
A.UV absorbance Matching UV
C.TLC Examination Matching TLC
D.Color reaction with Zn Matching Visual
Particle size 95% pass through sieve 80mesh Complies US Screen
Residual solvents ≤2.0% 0.06% HPGC
Light absorbing impurities Abs≤0.10 between 450-480nm 0.05 UV
Susbtance insoluble in methanol≤3.0% 0.80% CP2010
Impurity
A.Isoquercetin ≤2.0% 0.41% HPLC
B.Kaempferol3-Rutinoside ≤2.0% 1.45% HPLC
C.Quercetin ≤2.0% 0.04% HPLC
Total Impurity ≤4.0% 3.31% HPLC
Bulk density ≥0.30gm/cc 0.37gm/cc CP2010
Tapped density ≥0.50gm/cc 0.56gm/cc CP2010
Residual Solvents Methanol ≤0.3% <0.3% GC
Heavy metals ≤10ppm <10ppm Visual Colorimetry
-Arsenic ≤1ppm <1ppm AAS
-Mercury ≤0.1ppm <0.1ppm AAS
-Cadmium ≤1ppm <1ppm AAS
-Lead ≤3ppm <3ppm AAS
Ash ≤0.10% 0.08% CP2010
Loss on drying 7.5%-9.5% 8.60% 105C/3h
Assay(on dry basis) 95.0%-101.0% 99.94% UV
Microbiological test:
Total plate count ≤1000cfu/g 100cfu/g AOAC966.23
Mildew&Yeast ≤100cfu/g 20cfu/g FDABAM8th
E.Coli Negative Negative FDABAM8th
Salmonella Negative Negative FDABAM8th
Coliforms ≤10cfu/g <10cfu/g AOAC911.14
Enterobacteria Negative Negative FDABAM8th
Resticide Screen Meets the requirements of EP 8.
GMO/BSE Status Not genetically modified organism.Free of BSE
Storage Store in tight containers,in a cool dry area.

Signs You May Need Rutin

Most of the signs that you may benefit from rutin involve the circulatory system, especially the veins. Varicose veins in the legs and hemorrhoids are the strongest indication that rutin can help you. Additional conditions that may mean you need rutin include chronic venous insufficiency, in which the veins have difficulty in returning blood to the heart. You may also benefit from rutin if you have spider veins.

How It Works (Mechanisms)

Rutin is not an especially large flavonoid, but specific parts of its molecule interact with different systems in the body, such as the brain, heart, or blood vessels.

Analyse Items	Spesifikaasjes	Metoaden
Identifikaasjes
IR	IR-spektrum is konkordant mei it referinsjespektrum fan Rutin RS-<197K>
UV	Absorptiviteit op it maksimum by 358 nm is 30,5-33,0.<197U>
HPLC	Behâldtiid fan it stekproef komt oerien mei de standert yn HPLC suverenstest.
Oplosberens	Unoplosber yn wetter, licht oplosber yn ethanol.
Tests foar aktive yngrediïnten
Rutin (UV)	95.00%-101.00%	USP43<857>
Totale ûnreinheden	≤4,00%	USP43<621>
Kaempferol 3-rutinoside	≤2.00%	USP43<621>
Isoquercitroside	≤2.00%	USP43<621>
Quercetin	≤2.00%	USP43<621>
Net spesifisearre ûnreinheid	≤1.00%	USP43<621>
Fysike Tests
Ferskining	Yellow Green Fine Poeder	Fisueel
Grutte fan it dieltsje	NLT 95% passe 80mesh	USP43<786>
Wetter	7,50%-9,50%	USP43<921>
Residu op Ignition	≤0.10%	USP43<281>
Gemyske Tests
Swiere metalen	≤10.00ppm	USP43<231>
Pb	≤3.00ppm	USP43<211>
As	≤1.00ppm	USP43<251>
Cd	≤1.00ppm	USP43<232>
Hg	≤0,10 ppm	USP43<261>
Methanol Unoplosbere stof	≤3.00%	USP43<561>
Mikrobiologyske tests
Totaal oantal baktearjes	≤1.000 cfu/g	USP43<2021>
Gisten en skimmels	≤100 cfu/g	USP43<2021>
E. Coli	Negatyf yn 1g	USP43<2022>
Salmonella	Negatyf yn 10g	USP43<2022>
* Ferklearrings:Allergeenfrij, bestraald fergees, GMO fergees, Additiven fergees.

Relieves Arthritis Symptoms

Studies show that this antioxidant has the power to inhibit acute and chronic inflammation. That makes it a potential natural treatment for arthritis. Researchers in Russia found that rutin was able to reduce the overproduction of free radicals in rheumatoid arthritis. They concluded it can be considered a useful supporting pharmaceutical agent.

Additionally, a 2017 lab study published in Pharmacology found that rutin improved the formation of tissue over the joint’s surface, improved cartilage and bone erosion, and reduced inflammation.  This suggests that it has a protective effect against rheumatoid arthritis.

Vitamin C support

Rutin may work with vitamin C to enhance its effects, especially maintaining eye health and function.

Blood Vessel Health

Different studies have assessed rutin’s role in conditions affecting the blood vessels, including chronic venous insufficiency and varicose veins.

Chronic Venous Insufficiency

Chronic venous insufficiency (CVI) is a condition that affects the venous systems in the lower limbs. In CVI, the venous valves in the legs are not working correctly, causing blood to flow back downward and pool in the veins. This can cause leg discomfort, heaviness, cramps, and pain.

A systematic review published in the Journal of Clinical Pharmacy and Therapeutics in 2015 concluded that a partially synthetic derivative of rutin called hydroxyethylrutosides moderately improved symptoms of CVI.

Varicose Veins

Pregnancy can increase the risk of developing varicose veins, which occurs when the valves inside the veins weaken. As a result, the veins become enlarged and dark in appearance.

A report in the Cochrane Database of Systematic Reviews indicated that rutoside (a compound found in rutin) might help relieve the symptoms of varicose veins in late pregnancy. However, the study only included 69 women.

 

Prevents Blood Clots

Investigators at Harvard-affiliated Beth Israel Deaconess Medical Center found that rutin may serve as a novel strategy for preventing thrombosis. Thrombosis is when a blood clot forms in an artery or vein. Deep vein thrombosis is particularly dangerous because it can cause life-threatening complications, such as strokes and heart attacks.

Researchers found that rutin inhibits protein disulfide isomerase (PDI), which is rapidly secreted from our platelets and endothelial cells during thrombosis. By blocking the secretion of PDI, the antioxidant proved to block thrombosis.

Not only does it inhibit PDI, but it also prevents the compound from entering cells. Researchers found that it helped prevent blood clots in both arteries and veins, and it’s said to be the only agent that can prevent both types of clots.

 

Improves Circulation

In traditional medicine, rutin is known for its ability to strengthen blood vessels and improve circulation. It is used to reduce the appearance of varicose veins, relieve hemorrhoids and prevent hemorrhagic strokes that are caused by broken veins or arteries.

A review published in the International Journal of Molecular Sciences indicates that rutin preparations were reported to significantly reduce leg swelling, relieve leg pain, and reduce leg cramps, heaviness and itching. This is likely due to its ability to reduce inflammation and improve blood circulation.

For example, rutin contains two bound sugar molecules, which enhance its antioxidant effects on the brain.

Overall, rutin acts by:

• Protecting brain cells from damage

• Blocking inflammatory enzymes (phospholipase A2), similar to corticosteroids but without the side effects

• Reducing oxidative stress and free radicals

• Safely lowering high blood pressure, affecting similar pathways as drugs used for high blood pressure (blocks ACE)

• Boosting acetylcholine (by clocking the enzyme that degrades it, AChE)

• Binding to and neutralizing toxic compounds that build up in the body if exposed to radiation

• Relaxing blood vessels

 

About this item

• Packed with Antioxidants – Rutin contains several compounds called flavonoids which are antioxidant that’s essential for overall wellness.* Our Rutin supplement is sourced from Sophora japonica flower buds. And, add our Rutin powder to any diet and routine for daily intake of antioxidants!*

• For Overall Wellness – As a source of antioxidants, Rutin supplements are a great addition to your daily routine for overall wellness.* And, our Rutin supplements are perfect for people who are leading an active and healthy lifestyle, especially people always on the go!

• Soy Free & No Filler – Our Rutin 500mg powder, or Rutin powder, is free of soy, dairy, and added sugars which is suitable for those who has dietary restrictions. Not only it’s soy free, it also does not have any fillers, additives, and artificial flavors. And, take 500mg, which is about 1/5 tsp, for every serving of this herbal supplement.

• Add to your Diet – Our Rutin supplement is pure and natural product without any artificial flavors. Add our Rutin Powder into your diet to any beverage of our choosing like shakes, juice or just simply water, making it a great way to get the benefits of it in an easy to use powder form.

• High Quality – All products by 911healty are manufactured according to cGMP Standards to ensure the highest quality for manufacturing, packaging, labeling, and holding operations. We third party test our products at multiple stages during production, procedures and equipment to ensure compliance, standards and consistency.

 

What Are the Side Effects of Rutin?

Rutin is generally considered safe when consumed in the amounts which are recommended.